AMPK activator SC4

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AMPK 激活剂 SC4 是 α2β2-AMPK 复合物的有效特异性激活剂，对于 α2β2γ1 和 α2β2γ3 的 EC50 分别为 17.2 和 82.1 nM。

AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle; does not significantly stimulate activities of the α1-equivalent complexes α1β2γ1 and α1β2γ3 at 5 uM; Deletion β-subunit carbohydrate binding module (CBM) abolished SC4 activation; preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.

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SC-4 | SC 4 | SC4

Membrane Transporter/Ion Channel

AMPK

AMPK

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1364692-88-5

471.897

C26H18ClN3O4

>98% (HPLC)

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O=C(O)C1=CC(OC2=NC3=CC(Cl)=C(C4=CC=C(C5=CC=CC=C5O)C=C4)N=C3N2)=CC=C1C

5-((6-Chloro-5-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-3Himidazo[4,5-b]pyridin-2-yl)oxy)-2-methylbenzoic acid

(-20℃)

With Ice Pack

≥ 2 years